Gonadorelin Acetate2mg | 10mg

Gonadorelin Acetate is a synthetic decapeptide that mirrors the naturally occurring gonadotropin-releasing hormone (GnRH). It plays a pivotal role in regulating reproductive functions by stimulating the anterior pituitary gland to release two essential hormones: luteinizing hormone (LH) and follicle-stimulating hormone (FSH).

Mechanism of Action:

Upon administration, Gonadorelin Acetate binds to GnRH receptors on gonadotrope cells within the anterior pituitary. This interaction initiates a signaling cascade resulting in the secretion of LH and FSH. These gonadotropins then act on the gonads, facilitating processes such as ovulation in females and spermatogenesis in males.

Therapeutic Applications:

• In Women: Gonadorelin Acetate is employed to treat infertility stemming from hypothalamic dysfunction. It aids in inducing ovulation and can be instrumental in diagnosing reproductive disorders by evaluating the pituitary gland’s responsiveness to GnRH stimulation.
• In Men: The peptide is utilized to address hypogonadotropic hypogonadism, a condition characterized by insufficient production of sex hormones due to pituitary or hypothalamic issues. Treatment with Gonadorelin Acetate can stimulate testosterone production and support normal reproductive function.
• In Veterinary Medicine: Gonadorelin Acetate is used to treat ovarian follicular cysts and to synchronize estrous cycles in cattle. It also aids in addressing delayed ovulation and enhancing reproductive efficiency in dairy herds.

Chemical Properties:

• Molecular Formula: C₅₅H₇₅N₁₇O₁₃
• Molecular Weight: 1182.31 g/mol
• CAS Number: 34973-08-5 (acetate)

Storage and Stability:

For optimal stability, Gonadorelin Acetate should be stored at -20°C. Under these conditions, the lyophilized product remains stable for at least 18 months. Once reconstituted, it maintains stability for a minimum of 45 days at temperatures of 24°C or 37°C.

Safety Profile:

Gonadorelin Acetate is generally well-tolerated. However, in rare instances, severe anaphylactic reactions may occur following intravenous administration. It is advisable to administer this medication in settings equipped to manage potential systemic reactions.

Conclusion:

Gonadorelin Acetate serves as a critical tool in both human and veterinary medicine for managing and diagnosing various reproductive disorders. Its ability to effectively modulate the release of key gonadotropins underscores its significance in reproductive health interventions.