Chonluten, also called tripeptide T-34. Research suggests that Chonluten regulates the expression of a genes encoding antioxidant and anti-inflammatory pathways, particularly in the lungs and Gl tract[1]. This may explain why Chonluten is often used as a geroprotective agent (slowing or preventing the aging process) as well as an anti-inflammatory in the lungs where it seems to normalize mucosal function in the setting of conditions like COPD.
Tripeptides in Bioregulation
A number of small di-, tri-, and tetrapeptides have been shown to increase life span by as much as 40% in animal studies. They appear to do this in a number of ways, such as suppressing the development of both spontaneous and induced tumors. This fact, combined with a reduction in the rate at which age-related biomarkers decline, has led scientists to postulate that a number of tripeptides may regulate gene expression as well as cellular processes like apoptosis[2], [3].
Research indicates that short peptides can regulate all aspects of gene expression, including epigenetic DNA methylation [4]. Modeling studies have shown that a single short peptide can regulate dozens of genes by penetrating both cytoplasmic (cell) and nuclear membranes to bind directly to DNA via a simple docking method at promoter, suppressor, and other DNA control regions[5].
Given the extensive role that Russia has played over the decades in the isolation and development of peptides and peptide bioregulators, it should come as no surprise that the leading authority on Chonluten is Vladimir Khavinson. Dr. Khavinson is the current director of the St. Petersburg Institute of Bioregulation and Gerontology and has served on several international committees focused on geriatrics and gerontology. His works has made it clear that Chonluten and other short peptides can bind directly to DNA to produce their effects[6]. Dr. Khavinson indicates that Chonluten is just one of many short peptides that are ushering a new way of approaching both health and disease as we age.
Chonluten and the Lungs
Chonluten appears to have tissue specific activity in the lungs, altering DNA expression in a way that normalizes mucosa in the bronchi. This inner lining of the bronchi is the barrier between the outside world that we inhale with every breath and the inner workings of our cardiovascular system and, ultimately, our entire body. It can be altered via different inflammatory conditions, such as asthma or COPD, in ways that lead to changes in mucus production, extracellular matrix structure, and more. Smoker’s cough, for instance, is an inflammatory condition that leads to chronic irritation of the mucosal lining and subsequent chronic cough, phlegm production, and more.
Chonluten’s effects appear to be mediated through several genes include c-Fos, heath shock protein gene HSP70, SOD, COX-2, TNF-alpha, and genes within the antioxidant system. Regulation of most of these genes has obvious anti-inflammatory effects. Of particular interest, however, is c-FOS. The c-FOS protein is a potent general regulator of cell proliferation, differentiation, and survival. It is activated in response to cellular damage and hypoxia. While its effects at a local level can be useful, such as the growth of new blood vessels and the proliferation of cells following injury, widespread expression can lead to thickened bronchial mucosa and even the development of cancer. The ability to regulate c-FOX activity offers the ability to strike one of the underlying pathophysiological changes seen in asthma and COPD[1].
Chonluten and COVID-19
A peptide with active anti-inflammatory effects is of obvious interest to scientists during the global covid-19 pandemic. Research shows that Chonluten and its similar cousin Bronchogen are effective for the treatment of bronchopulmonary pathology. Chonluten appears to improve the effectiveness of standard therapy in the setting of chronic bronchitis with an asthmatic component and has stress-protective effects. Both of these features, combined with the fact that Chonluten improves physical performance and organism function state in the setting of low oxygen, might make this tripeptide a useful adjuvant in a multi-component cocktail for fighting covid-19[7].
Chonluten and the Gl Tract
The effects of chonluten in the Gl tract are similar, if muted, to its effects in the lungs. Research suggests that it may be useful in reducing inflammation and vascular changes in the Gl tract that result from inflammatory diseases like Crohn’s disease and ulcerative colitis. Research on this aspect of Chonluten is ongoing[1].
Chonluten Summary
Chonluten is a short peptide regulator of gene expression. It appears to be most active in lung tissue with secondary levels of activity in the Gl tract. It regulates genes related to inflammation and antioxidant activity as well as genes involved in proliferation responses to inflammation. Regulation of pulmonary mucosal function by Chonluten may have important applications in chronic inflammatory diseases of the lung such as asthma.
Chonluten exhibits minimal side effects, low oral and excellent subcutaneous bioavailability in mice. Per kg dosage in mice does not scale to humans. Chonluten for sale at Peptide Sciences is limited to educational and scientific research only, not for human consumption. Only buy Chonluten if you are a licensed researcher.
FAQs for Chonluten 20mg (Bioregulator)
1. What is Chonluten 20mg (Bioregulator)?
Chonluten 20mg is a bioregulator designed to support joint health and repair. It contains a special combination of peptides that target the regeneration of cartilage tissue and help in managing joint pain and inflammation. The bioregulator is formulated to promote the body’s natural healing processes and is commonly used by individuals dealing with osteoarthritis or joint-related conditions.
2. How does Chonluten 20mg work?
Chonluten works by promoting the synthesis of collagen and proteoglycans, which are vital components for cartilage regeneration. It helps stimulate the production of chondrocytes (cartilage cells), supports joint fluid production, and reduces inflammation in the affected joints. This combination assists in restoring joint mobility and reducing pain caused by degenerative conditions.
3. What are the key ingredients in Chonluten 20mg?
Chonluten 20mg primarily contains peptides derived from cartilage, particularly from bovine sources, along with other active compounds designed to support the structure and function of joints. These peptides act as bioregulators, specifically promoting the regeneration of damaged cartilage and improving overall joint health.
4. What are the potential benefits of using Chonluten 20mg?
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Supports cartilage regeneration and joint repair.
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Reduces inflammation and alleviates joint pain.
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Enhances joint mobility and flexibility.
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Stimulates the production of joint fluids.
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Helps prevent further cartilage degradation in chronic joint diseases such as osteoarthritis.
5. Who should use Chonluten 20mg?
Chonluten 20mg is typically recommended for individuals who suffer from joint pain, osteoarthritis, or cartilage degeneration. It may also be beneficial for those looking to maintain joint health and prevent deterioration due to aging or physical stress.
6. How should I take Chonluten 20mg?
The recommended dosage of Chonluten 20mg is typically one tablet per day, preferably taken with food for better absorption. However, the exact dosage and duration of use should be determined by a healthcare professional based on individual needs and medical history.
7. Are there any side effects of Chonluten 20mg?
Chonluten 20mg is generally considered safe for most individuals when used as directed. However, some people may experience mild digestive discomfort, such as bloating or nausea. If any adverse reactions occur, it is advised to stop use and consult a healthcare provider.
8. Can Chonluten 20mg be used alongside other medications?
Chonluten 20mg can be used alongside other medications, but it is important to consult a healthcare professional before combining it with other supplements or medications. This is particularly important for individuals on medications for joint health, anti-inflammatory drugs, or other chronic conditions.
9. How long will it take to see results with Chonluten 20mg?
Results from using Chonluten 20mg may vary depending on the severity of the joint issue. Many users report seeing noticeable improvements in joint mobility and pain reduction within 3-6 weeks of consistent use. However, for optimal results, long-term use might be necessary, and ongoing consultations with a healthcare provider are recommended.
10. Is Chonluten 20mg safe for long-term use?
Yes, Chonluten 20mg is designed for long-term use and is generally safe when taken as recommended. However, for chronic conditions, it is best to consult a healthcare professional for guidance on the most appropriate treatment plan.
11. Can Chonluten 20mg be used for sports injuries or acute joint trauma?
While Chonluten 20mg is primarily designed for chronic joint issues like osteoarthritis, it may also help in the recovery process for sports injuries or acute joint trauma by promoting cartilage repair and reducing inflammation. However, if you’re dealing with a recent injury, it’s essential to seek medical advice to ensure the right treatment approach.
12. Is Chonluten 20mg suitable for everyone?
Chonluten 20mg is suitable for most adults, especially those dealing with joint issues or seeking to improve their overall joint health. However, it may not be recommended for individuals who are pregnant, breastfeeding, or have certain health conditions like allergies to specific ingredients in the formula. Always consult a healthcare provider before starting any new supplement regimen.
13. Can Chonluten 20mg help with conditions other than joint pain?
Although Chonluten 20mg is mainly used for joint health, it may also support the repair of other connective tissues in the body. It is sometimes used to aid in the healing of soft tissues, cartilage, and ligaments in general.
14. Where can I purchase Chonluten 20mg?
Chonluten 20mg can be purchased from various pharmacies, health stores, and online retailers. It is important to buy from reputable sources to ensure you are receiving a genuine product.
15. Are there any lifestyle changes that can enhance the effects of Chonluten 20mg?
To maximize the benefits of Chonluten 20mg, it’s advised to maintain an active lifestyle with joint-friendly exercises (such as swimming or walking), maintain a healthy weight to reduce joint strain, and follow a balanced diet rich in vitamins and minerals that support joint health, including vitamin C, vitamin D, and omega-3 fatty acids.
Vendor: PeptideNationUSA
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I’ve been using this for a few weeks and noticed real improvements!